Adenovirus and Rotavirus

Adenovirus

Antibody

Antigen

Clones

ELISA

Genotyping

Rapid Tests

Reference Materials

Adenoviruses were first discovered in 1953, by Rowe and his colleagues. These viruses were first isolated from Adenoid cell culture, hence the family name of Adenoviridae. At present, 51 distinct serotypes have been recognized and recorded. Adenoviruses are non-enveloped icosahedral particles. The capsid is built up from 252 capsomers (T=25), of which 240 are hexavalent and 12 (situated at the apices) are pentavalent. A "penton fibre"projects from each apex

A group of viruses that infect the membranes (tissue linings) of the respiratory tract, the eyes, the intestines, and the urinary tract, adenoviruses account for about 10% of acute respiratory infections in children and are a frequent cause of diarrhea.

Diseases induced by different genotypes of Adenovirus

	Diseases	Genotpyes
	Keratoconjunctivitis epidemica	Type 8, 19, 37
	Acute respiratory infection	Type 1-3, 4,6,7, 14, 21
	Pharyngo-conjuctival fever	Type 3, 7, 14
	Follicular conjunctivitis	Type 3, 4, 7
	Gastroenteritis	Type 40, 41, 31
	Gastroenteritis with mesenterial lymphadenopathia	Type 1, 2, 5, 6
	Pneumonia	Type 1-4, 7
	Pharyngitis acute with fever	Type 1-3, 5-7

Adenovirus infection in children after allogeneic stem cell transplantation: diagnosis, treatment and immunity. Bone Marrow Transplant. 2005 Mar;35 Suppl 1:S73-6.

Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver by Adenovirus-mediated gene transfer. J Lipid Res. 2006 Jun 1

Emerging viral infections after hematopoietic cell transplantation. Pediatr Transplant. 2005 Dec;9 Suppl 7:48-54.

Rotavirus